Results 131 to 140 of about 229,517 (308)

The impact of the COVID-19 pandemic and the free vaccination policy on seasonal influenza vaccination uptake among older adults in Ningbo, Eastern China

Human Vaccines & Immunotherapeutics
In 2020–21, during the COVID-19 pandemic, a free influenza vaccination program was initiated among the elderly residents in Ningbo, China. The impact of the COVID-19 pandemic and free vaccination policy on influenza vaccine uptake needs to be evaluated ...
Lixia Ye, Jieping Chen, Qiuhong Mei, Yexiang Sun, Tianchi Yang   +4 more
doaj   +1 more source

Low coverage rate and awareness of influenza vaccine among older people in Shanghai, China: A cross-sectional study

Human Vaccines & Immunotherapeutics, 2018
Background: Older individuals are at high risk for morbidity and mortality due to influenza, and the most effective way to prevent influenza is yearly vaccination.
Chuchu Ye, Weiping Zhu, Jianxing Yu, Zhongjie Li, Wenbiao Hu, Lipeng Hao, Yuanping Wang, Hongmei Xu, Qiao Sun, Genming Zhao   +9 more
doaj   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Impact of propensity to COVID-19 vaccination/vaccine on influenza vaccination from willingness to behavior among older adults in rural China

Human Vaccines & Immunotherapeutics
To explore impact of the propensity to coronavirus disease 2019 (COVID-19) vaccine/vaccination on influenza vaccination from willingness to behavior after COVID-19 pandemic among older adults in rural China.
Shan-Shan Zhang, Wanna Shi, Juan Du, Wan-Xue Zhang, Mengjun Yuan, Yiguo Zhou, Lili Wang, Tianshuo Zhao, Qin-Yi Ma, Sihui Zhang, Han Yang, Xiyu Zhang, Mingting Wang, Ninghua Huang, Jing Zeng, Yaqiong Liu, Yuanshan Zhang, Fuqiang Cui, Qing-Bin Lu   +18 more
doaj   +1 more source

Knowledge about influenza and adherence to the recommendations for influenza vaccination of pregnant women after an educational intervention in Greece

Human Vaccines & Immunotherapeutics, 2019
Pregnant women and young infants are at increased risk for influenza-associated severe disease, complications and hospitalizations. In Greece influenza vaccination during pregnancy remains extremely low.
Helena C. Maltezou, Pelopidas Pelopidas Koutroumanis, Chrissa Kritikopoulou, Kalliopi Theodoridou, Panos Katerelos, Ioanna Tsiaousi, Alexandros Rodolakis, Dimitrios Loutradis   +7 more
doaj   +1 more source

Vaccination nation? Civilised strategies for protecting outdoor poultry from Avian Flu H5N1 [PDF]

, 2006
An analysis of the threat of H5N1 Avian Flu virus to the UK, the potential impact on UK organic and free range poultry production and the evidence for a policy of ...
Sanders, Richard
core  

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Effect of Perceived Stress on Cytokine Production in Healthy College Students [PDF]

, 2015
Chronic psychological stress impairs antibody synthesis following influenza vaccination. Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis.
McCarthy, Donna O., Neal, Jeremy L., Sribanditmongkol, Vorachai, Szalacha, Laura A.   +3 more
core   +1 more source

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

Advanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin, Lu‐Jun Zhou, Hui‐Lin Ye, Ting Liu, Bo‐Yan Chen, Xue‐Bing Bai, Jun Zhang, Lan Bai, Lin‐Juan Du, Yuan Liu, Yong‐Li Wang, Hong Zhu, Yu‐Lin Li, Shuo Xu, Xiao‐Qian Meng, Guo‐Cai Tian, Yan Liu, Wu‐Chang Zhang, Ya‐Qin Zhu, Sheng‐Zhong Duan   +19 more
wiley   +1 more source