Results 201 to 210 of about 677,032 (302)

Immunopotentiation by Natural Extracts: Mechanisms and Applications in Influenza Vaccine Adjuvant Development. [PDF]

Food Sci Nutr
Ho TL, Ko EJ.
europepmc   +1 more source

Engineering Antibody Evolution: Germline‐Targeting HIV Vaccines Reach a Turning Point

Immunology &Cell Biology, EarlyView.
This commentary examines three recent Nature studies demonstrating a conceptual shift in HIV vaccine design, demonstrating how germline‐targeting HIV vaccines can progress beyond expanding rare broad neutralizing antibody (bnAb) precursors to deliberately guiding their affinity maturation into bnAbs in non‐human primates.
Rowena A. Bull, Deborah L. Burnett
wiley   +1 more source

A Bayesian Re-analysis of the GALFLU Trial of High-Dose vs Standard-Dose Influenza Vaccine Against Hospitalization Outcomes. [PDF]

Clin Infect Dis
Pardo-Seco J, Rodriguez-Tenreiro-Sánchez C, Giné-Vázquez I, Mallah N, Mirás-Carballal S, Piñeiro-Sotelo M, Cribeiro González M, Conde Pájaro M, González-Pérez JM, Rivero-Calle I, Bello X, Razzini JL, Salas A, Harris RC, Loiacono MM, van Aalst R, Farre M, Dufournet M, Dyrby Johansen N, Modin D, Biering-Sørensen T, Duran-Parrondo C, Martinón-Torres F, GALFLU Trial Team.   +23 more
europepmc   +1 more source

Australian consensus recommendations for the management of increased meningococcal infection risk in adults with neurological diseases treated with complement inhibitors

Internal Medicine Journal, EarlyView.
Abstract Complement inhibitor therapy carries a risk of serious infections, including meningococcal disease. Here we provide evidence‐based recommendations and expert consensus for immunisation and prophylactic treatment of patients receiving, or planning to receive, complement inhibitors for neurological conditions in the Australian setting.
Katherine A. Buzzard, Michael Barnett, Heidi Beadnall, Mirasol Forcadela, Lesley‐Ann Hall, Victoria G. Hall, Todd Hardy, Danny Hsu, Paul Kinsella, Mastura Monif, Sudarshini Ramanathan, Stephen W. Reddel, Sean Riminton, Douglas F. Johnson   +13 more
wiley   +1 more source

Poor sleep impairs immune responses and influenza vaccine protection. [PDF]

Nat Commun
Guan M, Gu W, Gileles-Hillel A, Khalyfa A, Balamalaliyage P, Tunterak W, Li M, Huang Y, Wen Y, Driver J, Gozal D, Wan XF.   +11 more
europepmc   +1 more source

Preventing infections after CD19‐directed chimeric antigen receptor T‐cell therapies for lymphoma: a consensus practice statement

Internal Medicine Journal, EarlyView.
Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley, Philip George, Gemma Reynolds, Adam Stewart, Hang Quach, Nicole O'Leary, Zoe McQuilten, Andrea S. Henden, Lynette Chee, Chan Y. Cheah, Olivia Bupha‐Intr, Emily Blyth, Ben Teh, Monica Slavin, Michael Dickinson, Robert Weinkove   +15 more
wiley   +1 more source

mRNA-based influenza vaccine expands the B cell response breadth in humans. [PDF]

Nat Immunol
Matz HC, Yu TG, Dixit K, Kikawa C, Zhou JQ, Pena Alzua G, Peyton L, Madsen A, Han F, Farrell AG, Hoelzl R, Schmitz AJ, Horvath SC, Keplinger HK, Strnad BS, Hoegger MJ, Middleton WD, Klebert MK, Lin NH, Nachbagauer R, Krammer F, Paris R, Bloom JD, Turner JS, Presti RM, Lee J, Ellebedy AH.   +26 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Influenza Vaccine Immunogenicity in Hemodialysis Patients. [PDF]

Vaccines (Basel)
Shurygina AP, Romanovskaya-Romanko E, Krivitskaya V, Sergeeva M, Buzitskaya J, Vasilyev K, Shuklina M, Vishnevskii K, Dmitry S, Aleksey T, Lioznov D, Stukova M.   +11 more
europepmc   +1 more source

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source