Results 211 to 220 of about 536,784 (299)

Systematic Identification of the Functional lncRNAs During H7N9 Avian Influenza Virus Infection in Mice. [PDF]

Viruses
Wang G, Hu Z, Cai X, Hu S, Gu M, Wang X, Peng D, Hu J, Liu X.   +8 more
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Case Report: Detection and characterization of avian influenza virus H9N2 in a broiler farm in Mozambique, 2025. [PDF]

Front Vet Sci
Monjane IVA, Nhabomba V, Tamele E, Djedje H, Sussuro A, Van-Dúnem TM, Mandlate I, Arone DM, Massicame ZE, Massingue J, Tivane AR, Chilaúle JJ, Zacarias D, Chaúque D, Mulungo D, Lamien CE, Meki IK, Dundon WG.   +17 more
europepmc   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

The Airway Microbiome as a Modulator of Influenza Virus Infection: Mechanistic Insights and Translational Perspectives-Review. [PDF]

Pathogens
Gioula G, Exindari M.
europepmc   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Effect of pH on small-molecule inhibitor binding to influenza virus hemagglutinin. [PDF]

J Biol Chem
Anirudhan V, Gaisina I, Shimon A, Lee H, Alqarni S, Manicassamy B, Moore TW, Xu K, Caffrey M, Rong L.   +9 more
europepmc   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source

Phylodynamic reconstruction of H1N1pdm09 influenza virus transmission in Brazil: a decade of evolutionary dynamics. [PDF]

Emerg Microbes Infect
Brcko IC, de Souza VC, Jeronimo Lima AR, Pereira JS, de Araújo ESA, Valeiros APNV, Palmieri M, Nunes JA, Torres LS, Santos HO, Leite AB, Pereira FM, de Mello ALES, Brandão Nardy V, de Andrade GSM, Astete Gomez MK, Vieira LL, Roll MM, Henrique BVM, Lima Neto LG, Cristina de Oliveira E, Almeida JDPC, da Silva SF, Vasconcelos KR, Adelino TER, Guimaraes NR, Ribeiro Tomé LM, Arend LNVS, da Silva CC, Maia ACS, Mattos CB, Costa GDS, Alcântara LC, Kallás EG, Sampaio SC, Slavov SN, Giovanetti M, Elias MC.   +37 more
europepmc   +1 more source