Results 141 to 150 of about 1,206,985 (356)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

open access: yesAdvanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu   +11 more
wiley   +1 more source

Informatics Research Institute (IRIS) September 2008 newsletter [PDF]

open access: yes, 2008
2007-8 was a very busy year for IRIS. It was a bumper year for visiting Profs with Prof Michael Myers visiting from New Zealand, Prof Brian Fitzgerald visiting from University of Limerick, Ireland, Prof.
Vadera, S
core  

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

open access: yesAdvanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang   +21 more
wiley   +1 more source

EXPERT SYSTEMS [PDF]

open access: yes
In recent decades IT and computer systems have evolved rapidly in economic informatics field. The goal is to create user friendly information systems that respond promptly and accurately to requests.
Georgiana Marin, Mihai Catalin Andrei
core  

Medical informatics [PDF]

open access: yesBMJ, 1995
R, Jones, S, Kinn, F, Grainger
openaire   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

open access: yesAdvanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li   +5 more
wiley   +1 more source

E-Commerce Project Management Implementation [PDF]

open access: yes
It is defined the informatics application interface concept and it is presented the role of this one in software using. There are pointed out the interface characteristics and the factors which lead to their efficiency.
Cristian Toma, Ion Ivan, Saha Priyatosh
core  

Environmental informatics [PDF]

open access: yesEnvironmental Modelling & Software, 2006
Hilty, Lorenz M   +2 more
openaire   +1 more source

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