Results 181 to 190 of about 1,140,283 (405)

Integrating Spatial and Single‐Nucleus Transcriptomic Data to Assess the Effects of Intrauterine Hyperglycemia on Fetal Pancreatic Development

open access: yesAdvanced Science, EarlyView.
Maternal pregestational diabetes mellitus (PGDM) induced metabolic stress in fetal mice pancreas, alongside significantly decreased insulin secretion, altered cell‐cell communication, and distinct changes in cellular niches. Abstract Maternal pregestational diabetes mellitus (PGDM) can lead to adverse fetal outcomes, including lasting impacts on ...
Yu Deng   +3 more
wiley   +1 more source

Work Informatics — An Operationalisation of Social Informatics [PDF]

open access: yes, 2007
A new approach to informatics and Social Informatics is introduced called Work Informatics. It is compared with Social Informatics, and it turns out that there is a high resemblance between their scopes and objectives. Work Informatics is more operational and therefore, we can use it more easily for practical purposes.
openaire   +2 more sources

CPL‐Diff: A Diffusion Model for De Novo Design of Functional Peptide Sequences with Fixed Length

open access: yesAdvanced Science, EarlyView.
This study presents a diffusion model for generating functional peptide sequence lengths using mask control. The model can generate antimicrobial, antifungal, and antiviral peptides with specific lengths on demand. The model learns the structure of peptides better and generates peptides with better physicochemical properties, and the model has good ...
Zhenjie Luo   +5 more
wiley   +1 more source

A comprehensive classification system for lipids1

open access: yesJournal of Lipid Research, 2005
Lipids are produced, transported, and recognized by the concerted actions of numerous enzymes, binding proteins, and receptors. A comprehensive analysis of lipid molecules, “lipidomics,” in the context of genomics and proteomics is crucial to ...
Eoin Fahy   +16 more
doaj  

Information society policies 2.0: a critical analysis of the potential and pitfalls of social computing & informatics in the light of e-inclusion [PDF]

open access: yes, 2010
In this paper we reflect on how research and policies can and/or should help in the development of a sustainable information society for all. More specifically, we critically investigate how social computing & informatics can entail both potential and ...
Verdegem, Pieter
core   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang   +18 more
wiley   +1 more source

Comparison of Large Language Model with Aphasia

open access: yesAdvanced Science, EarlyView.
Large language models (LLMs) answer almost all questions fluently but often inaccurately, which resembles a specific type of aphasia in humans. Using a data‐driven analysis called energy landscape analysis, this study reveals similarities in the internal information dynamics between LLMs and the brains of humans with receptive aphasia, such as Wernicke'
Takamitsu Watanabe   +4 more
wiley   +1 more source

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