Results 331 to 340 of about 1,140,283 (405)

A Recognition Tag of Human Origin for Bioorthogonal Generation of Antibody‐Drug Conjugates using Microbial Biotin Ligase

open access: yesChemBioChem, EarlyView.
A human‐derived recognition tag of Pyrococcus horikoshii biotin ligase is fused to the monoclonal antibody trastuzumab at the C‐termini of either light or heavy chain. These fusion antibodies allow for the PhBL‐mediated introduction of desthiobiotin azide and the subsequent attachment of DBCO‐AF488 and DBCO‐Val‐Cit‐PAB‐MMAE via strain‐promoted azide ...
Peter Bitsch   +5 more
wiley   +1 more source

Facilitating Reproducibility in Catalysis Research with Managed Workflows and RO‐Crates: A Galaxy Case Study

open access: yesChemCatChem, EarlyView.
This article demonstrates how the Galaxy workflow environment and RO‐Crates facilitate alignment with FAIR principles for catalysis research data. Selected XAS examples illustrate how packaged data can be produced directly from processing and analysis, enhancing reproducibility and replicability. This approach improves current data management practices,
Abraham Nieva‐de‐la‐Hidalga   +8 more
wiley   +1 more source

A Case Study Exploration of Adolescents’ Experiences in a Paid Summer Internship Program

open access: yesThe Career Development Quarterly, EarlyView.
ABSTRACT Adolescence is a critical time for career exploration, and internships are a common tool to promote career development. Yet, few researchers have examined their impact on participants. In this study, we conducted a qualitative case study with adolescent participants (N = 19) in the City of Charlotte's Mayor's Youth Employment Program (MYEP), a
Willough Davis   +2 more
wiley   +1 more source

Efficient and model‐agnostic parameter estimation under privacy‐preserving post‐randomization data

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Balancing data privacy with public access is critical for sensitive datasets. However, even after de‐identification, the data are still vulnerable to, for example, inference attacks (by matching some keywords with external datasets). Statistical disclosure control (SDC) methods offer additional protection, and the post‐randomization method ...
Qinglong Tian, Jiwei Zhao
wiley   +1 more source

Synthesis, Antimycobacterial Activity and Computational Insight of novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates Against Multidrug‐Resistant M. tuberculosis

open access: yesChemMedChem, Accepted Article.
To search for new antitubercular agents, we have designed, synthesized, and evaluated a series of 1,4‐benzoxazinone‐based compounds. These molecules showed potent antimycobacterial activity, with MIC between 2 and 8 μg/mL. This interesting profile included activity against several drug‐resistant strains and minimal cytotoxicity against mammalian Vero ...
Daniele Zampieri   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy