Results 341 to 350 of about 1,140,283 (405)

Designing an interoperable solution to support pharmacogenomic-guided prescribing in primary care: an implementer report. [PDF]

BMJ Health Care Inform
Sharma V, McDermott J, Keen J, McIntyre B, Watson S, Newman W.   +5 more
europepmc   +1 more source

Improved C5‐Amide Bioisosteres for Human Neuraminidase 1 Inhibitors Based on 2‐Deoxy‐2,3‐Didehydro‐N‐Acetyl Neuraminic Acid

ChemMedChem, EarlyView.
This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Mostafa Radwan, Elisa G. Carvajal, Christopher W. Cairo   +2 more
wiley   +1 more source

The emergence of large language models as tools in literature reviews: a large language model-assisted systematic review. [PDF]

J Am Med Inform Assoc
Scherbakov D, Hubig N, Jansari V, Bakumenko A, Lenert LA.   +4 more
europepmc   +1 more source

Novel quinazolinones active against multidrug‐resistant Mycobacterium tuberculosis: synthesis, antimicrobial evaluation and in silico exploration of PonA1 as a potential target

ChemMedChem, Accepted Article.
Quinazolinone derivatives have emerged as promising scaffolds in antimicrobial drug discovery. This work focuses on the design, synthesis, and evaluation of novel quinazolinone‐based compounds and predicts their potential to interact with mycobacterial penicillin‐binding proteins (PBPs).
MAREK KERDA, Daria Nawrot, Petr Slechta, Mirek Domanský, Asal Askari, Hanieh Kamangar, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Ingrid Hlbočanová, Miloslav Macháček, Matteo Mori, Fiorella Meneghetti, Martin Doležal, Jan Zitko, Ghada Bouz   +15 more
wiley   +1 more source

Multi-Agent Approach for Sepsis Management. [PDF]

Healthc Inform Res
Iapascurta V, Fiodorov I, Belii A, Bostan V.   +3 more
europepmc   +1 more source

Data science and artificial intelligence in biology, health, and healthcare. [PDF]

J Clin Transl Sci
Elkin PL, Lindsell C, Facelli J, Desai M, Weng C, Spratt H, Messinger S, Waitman LR, Hairston J, O'Hara R, Meinzen-Derr J.   +10 more
europepmc   +1 more source

Energy Landscapes in Chemical Reactions and Transport

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
Kinetics/dynamics of chemical reactivity and transport of chemical species in a solid are both determined by the energy landscape in which they take place. Discussing common grounds but also distinct differences may help in advancing the understanding in both fields.
Karl‐Michael Weitzel
wiley   +1 more source

Media Framing and Portrayals of Ransomware Impacts on Informatics, Employees, and Patients: Systematic Media Literature Review.

J Med Internet Res
Avery A, Baker EW, Wright B, Avery I, Gomez D.   +4 more
europepmc   +1 more source

Simultaneous Ring‐Opening and Dehydrogenation of Diarylethene Induced by Tunneling Electrons

ChemPhysChem, Volume 26, Issue 7, April 1, 2025.
Injection of tunneling electrons into LUMO of a closed‐form diarylethene derivative triggers a ring‐opening reaction with dehydrogenation, anchoring the molecule to the Cu(111) substrate. Scanning tunneling microscopy images revealed changes in brightness and angles between “wings” of the molecule, distinct from the open‐form isomer.
Hirokazu Sato, Taehwan Lee, Minhui Lee, Emiko Kazuma, Yousoo Kim, Jaehoon Jung, Kyoung Chul Ko, Tomoko K. Shimizu   +7 more
wiley   +1 more source