Results 41 to 50 of about 1,206,985 (356)
Frontiers in Pharmacology, 2018 Pharmacovigilance consists in monitoring and preventing the occurrence of adverse drug reactions. This activity can be time-consuming because it requires the collection of both patient and medication information.
Thibault Ledieu +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
A Multifunctional, Low Cost and Sustainable Neonatal Database System
ChildrenContinuous improvement in the clinical performance of neonatal intensive care units (NICU) depends on the use of locally relevant, reliable data. However, neonatal databases with these characteristics are typically unavailable in NICUs using paper-based ...
Joaquim M. B. Pinheiro +14 more
doaj +1 more source
PRINCIPLES, BASES, AND LAWS OF FUNDAMENTAL INFORMATICS
Открытое образование (Москва), 2016 This paper defines the goals and problems of fundamental informatics, formulates principal laws of information universe and constructive bases of information objects and processes.
Gennady N. Zverev
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Engineering Polymer Informatics [PDF]
, 2007 The poster describes a strategy of for the development of polymer informatics. In particular, the development of polymer markup language, a polymer ontology and natural language processing tools for polymer ...
Adams, Nico +4 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Neurocognitive Informatics Manifesto. [PDF]
, 2009 Informatics studies all aspects of the structure of natural and artificial information systems. Theoretical and abstract approaches to information have made great advances, but human information processing is still unmatched in many areas, including ...
Duch, Wlodzislaw
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Challenges of ultra large scale integration of biomedical computing systems [PDF]
, 2005 The NCRI Informatics Initiative is overseeing the implementation of an informatics framework for the UK cancer research community. The framework advocates an integrated multidisciplinary method of working between scientific and medical communities. Key
Begent, R. +7 more
core +1 more source