ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Modeling information literacy in Chinese physical education: the roles of technology integration, teaching practices, self-efficacy, and academic performance. [PDF]
Sci RepZhang X, Tian H.
europepmc +1 more source
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
How to make sense of information about COVID-19 and the vaccine from the authorities? A qualitative study of migrants' experiences in two Swedish communities. [PDF]
PLOS Glob Public HealthBäärnhielm S +4 more
europepmc +1 more source
Use and perceptions of information among family physicians: sources considered accessible, relevant, and reliable [PDF]
, 2013 Julie Kosteniuk +2 more
openalex +1 more source
Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins
FEBS Open Bio, EarlyView.We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó +7 more
wiley +1 more source
Genie in the bottle? a qualitative study of general practitioners' perspectives and information needs concerning digital mental health applications in Germany. [PDF]
BMC Prim CareSahan F +10 more
europepmc +1 more source
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2019 Berge, Solberg, Torbjørn, Dahl
openaire +1 more source
Towards Information-Centric Networking (ICN) Naming for Internet of Things (IoT) [PDF]
, 2017 Sobia Arshad +3 more
openalex +1 more source