Results 91 to 100 of about 1,405,618 (304)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Digital Preservation and Web Access to the Konkoly Observatory Schmidt Telescope Plate Archive [PDF]

open access: yes, 2012
ACM Computing Classification System (1998): J.2.The digital preservation of the Konkoly Observatory Schmidt telescope plates, as well as the web access to the plate previews, aim for the preservation of this scientific heritage and the re-use of the ...
Holl, András   +2 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

An Object memory for an object-oriented database management system [PDF]

open access: yes, 1988
Ankara : The Department of Computer Engineering and Information Sciences and the Institute of Engineering and Sciences of Bilkent Univ. , 1988.Thesis (Master's) -- Bilkent University), 1988.Includes bibliographical references leaves 86-89.Object-oriented
Kesim, F Nihan
core  

On sparse representations of linear operators and the approximation of matrix products

open access: yes, 2009
Thus far, sparse representations have been exploited largely in the context of robustly estimating functions in a noisy environment from a few measurements. In this context, the existence of a basis in which the signal class under consideration is sparse
Belabbas, Mohamed-Ali, Wolfe, Patrick J.
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

A Comparative Study of Maze Generation Algorithms in a Game-Based Mobile Learning Application for Learning Basic Programming Concepts

open access: yesAlgorithms
This study evaluates several maze generation algorithms applied to generate mazes in a game-based Android mobile application designed to support children in learning basic programming concepts and computational thinking.
Mia Čarapina   +3 more
doaj   +1 more source

Cybernetics, Fuzziness and Scientific Revolutions [PDF]

open access: yes, 2015
Settimo Termini ​pioneered along with Aldo de Luca the concept of fuzziness measures in the sixties. Today he is a Full Professor of Theoretical Computer Science at the University of Palermo and an affiliated researcher at the European Center for Soft
Lincetto, M   +3 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

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