Results 101 to 110 of about 996,337 (284)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The effect of culture on online learning [PDF]
, 2010 The author is conducting survey research to identify possible effects of\ud culture on online learning success. The research will consider the cultural\ud dimension of uncertainty avoidance identified by Hofstede (2001). The research\ud participants will
Kinasevych, Orest
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Shaping Current Waveforms for direct Modulation of Semiconductor Lasers
, 2004 We demonstrate a technique for shaping current inputs for the direct modulation of a semiconductor laser for digital communication. The introduction of shaped current inputs allows for the suppression of relaxation oscillations and the avoidance of ...
Illing, L., Kennel, M. B.
core +2 more sources
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Avoidance maneuevers selected while viewing cockpit traffic displays [PDF]
Ten airline pilots rates the collision danger of air traffic presented on cockpit displays of traffic information while they monitored simulated departures from Denver. They selected avoidance maneuvers when necessary for separation.
Ellis, S. R., Lee, E., Smith, J. D.
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Report on adjusting a high throughput screening tool to support water use phenotyping in forages [PDF]
, 2020 Drought severely limits forage productivity. The avoidance of water deficit by increasing the capacity for water uptake or by controlling water loss are common responses.
Cardoso Arango, Juan Andrés
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
PENGARUH TAX AVOIDANCE TERHADAP NILAI PERUSAHAAN (Studi Empiris Terhadap Perusahaan Manufaktur yang Terdaftar di BEI tahun 2011-2014) [PDF]
, 2017 The Effect of Tax Avoidance towards Firm Value The objectives of this study are to obtain empirical proof and analyze tax avoidance behavior effect which is calculated using the Tobins’ Q proxy, towards firm value.
ADITYA , SW Yohanes, PURWANTO, Agus
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