Results 51 to 60 of about 2,161,269 (246)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Analysis of the Impact of Information Behavior on the Marketing and Fertilization Strategies of Small Cocoa Producers in the Provinces of Guayas and Los Ríos in Ecuador

open access: yesAgriculture
The main barriers faced by small-scale cocoa producers in Ecuador are the limited access to and the use of information technologies, which affects their efficiency in production and marketing.
Ivonne Soraya Burgos Villamar   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Recent trends in user studies: action research and qualitative methods

open access: yesInformation Research: An International Electronic Journal, 1998
This paper was commissioned by Professor Gernot Wersig of the Freie Universität, Berlin in 1980, as part of his Project, Methodeninstrumentarium zur Benutzforschung in Information und Dokumentation.
T.D. Wilson
doaj  

Cognitive Components Analysis in Therapists\' Information Seeking Behavior Using Neuroscience Research Tools

open access: yesIranian Journal of Information Processing & Management, 2020
This study is to explore the cognitive components of therapists' information seeking behavior in the diagnosis and treatment of mental disorders.
Ali Akbari, , Reza Rostami, Ali Moghimi
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Individual Differences in Undergraduate Students’ Collaborative Information Seeking Behavior When Working on Group Projects: A Study on Willingness to Collaborate and Sources Used [PDF]

open access: yesJournal of Library and Information Studies, 2019
Small-group teaching has been a preferred pedagogy in higher education, and it requires to communicate or seek information with peers. Therefore, collaborative information seeking (CIS) plays an important role in students’ group projects.
Chun-Hsien Chuang, Tien-I Tsai
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Fake News in Social Media: Bad Algorithms or Biased Users?

open access: yesJournal of Information Science Theory and Practice, 2019
Although fake news has been present in human history at any time, nowadays, with social media, deceptive information has a stronger effect on society than before.
Franziska Zimmer   +3 more
doaj   +1 more source

The Linguistic Obstacles of Bilingualism Phenomenon to Turkmen-Persian Bilingual Students’ Information Behavior [PDF]

open access: yesتحقیقات کتابداری و اطلاع‌رسانی دانشگاهی, 2013
Objective: It appears that bilingualism affects bilingual users’ information behavior in information environments. The study aims to investigate the role of linguistic obstacles to Turkmen-Persian bilinguals’ information behavior.
Heidar Mokhtari, Seif Allah Molayee
doaj   +1 more source

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