Results 51 to 60 of about 24,894,856 (287)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
IEEE Open Journal of the Communications SocietyA generic distributed / multiterminal setup is considered here wherein, through a joint design, several intermediate nodes must locally quantize their noisy observations from various sets of potentially common and uncommon user ...
Shayan Hassanpour +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
SDP Methods for Sensitivity-Constrained Privacy Funnel and Information Bottleneck Problems
2021 IEEE International Symposium on Information Theory (ISIT), 2021 We generalize the information bottleneck (IB) and privacy funnel (PF) problems by introducing the notion of a sensitive attribute, which arises in a growing number of applications. In this generalization, we seek to construct representations of observations that are maximally (or minimally) informative about a target variable, while also satisfying ...
Yuheng Bu, Tony Wang, Gregory W. Wornell
openaire +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Machines, 2023 There is a lack of high correlation and reuse potential among multiple manufacturing data for textiles and apparel. Moreover, the material flow traceability between production workstations is not clear, making it difficult to detect potential production ...
Guodong Wang, Guohua Liu, Qianqian Li
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Applied Sciences, 2018 In high-throughput applications, low-complexity and low-latency channel decoders are inevitable. Hence, for low-density parity-check (LDPC) codes, message passing decoding has to be implemented with coarse quantization—that is, the exchanged ...
Maximilian Stark +2 more
doaj +1 more source