Results 271 to 280 of about 9,537,607 (348)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Treatment of retroperitoneal sarcoma in Germany between 2000 and 2022: a retrospective analysis from the German Cancer Registry Group. [PDF]

J Cancer Res Clin Oncol
Beck N, Goßmann F, Hohenberger P, Kasper B, Menge F, Deinzer CKW, Franke B, Hendricks A, Klinkhammer-Schalke M, Rausch K, Reinwald F, Robers G, Kim-Wanner SZ, Schneider C, Wiegering A, Sabet-Rashedi M, Zeissig SR, Jakob J.   +17 more
europepmc   +1 more source

Hand in Glove: Health Equity and Learning Health Systems. [PDF]

Learn Health Syst
Bryant SL, Perry GJ, Wheeler TR.
europepmc   +1 more source

Measurement-induced phase transitions in informational active matter. [PDF]

PNAS Nexus
VanSaders B, Fruchart M, Vitelli V.
europepmc   +1 more source

Impact of a Prehospital Chest Pain Alert App-Mediated Prehospital-in-Hospital Coordination Model on Treatment Delays and Clinical Outcomes in Patients With ST-Elevation Myocardial Infarction: Protocol for a 4-Year Retrospective Real-World Cohort Study.

JMIR Res Protoc
Chen S, Wang R, Ma J, Xiao W, Song C.
europepmc   +1 more source

Comparing Complication Rates in Procedures Performed in the Operating Room Versus In-Office: A Cohort Study. [PDF]

Hand (N Y)
Carter JT, Rock J, Coffman J, Desai K, Person D, Srinivasan R.   +5 more
europepmc   +1 more source

Website quality, expectation, confirmation, and end user satisfaction: the knowledge-intensive website of the Korean National Cancer Information Center.

J Med Internet Res, 2011
Koo C, Wati Y, Park K, Lim MK.
europepmc   +1 more source