Results 201 to 210 of about 15,311,848 (309)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Evaluation of a general practitioner-based rehabilitation follow-up consultation to promote patients' use of medical rehabilitation aftercare: study protocol for a pragmatic cluster randomized crossover trial. [PDF]

BMC Health Serv Res
Lukasczik M, Seeger J, Küffner R, Vogel H.   +3 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Acceptability of Self-Help Plus and Problem Management Plus interventions among clients and implementation insights from staff of Opioid Agonist Treatment programs in Ukraine. [PDF]

PLOS Ment Health
Klymchuk V, Gorbunova V, Romanchuk V, Ivanchuk I.   +3 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Measuring "third places": Comparing neighborhood data for cognitive health research. [PDF]

Alzheimers Dement
Finlay JM, Rigby D, DeJohn A, Sun Y, Davis BA, Aldulaimy A, Alvarez-McNelis D, Bowie A, Hawkins K, Lin Z, Kan W, Ketterhagen TS, Lin X, Liwur SB, Sagehorn M, Sullivan L, Vaughan L, Zhu S, Berry A, Hicken MT, Esposito MH.   +20 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Impact of a Prototype Combining Recommender Functionality With Structured Documentation on Operator Performance in Calls to Medical Communication Centers: Quasi-Experimental Feasibility Study. [PDF]

JMIR Form Res
Fotland SS, Berge A, Zakariassen E, Midtbø V, Baste V, Fonnes G, Guribye F, Trattner C, You J, Johansen IH.   +9 more
europepmc   +1 more source

ALIGNED Network for rare cerebrovascular diseases: methodology and preliminary results. [PDF]

Neurol Sci
De Toma C, Potenza A, Rifino N, Strazzabosco C, Storti B, Marinoni G, Carrozzini T, Gorla G, Pollaci G, Pasella E, Mallia A, Canavero I, Boncoraglio GB, Scala I, Zacarias E, Fusi G, De Giorgi F, Foschi M, Sacco S, Caulo M, Banfi C, Gatti L, Bersano A, ALIGNED project.   +23 more
europepmc   +1 more source

Implementation of exclusive enteral nutrition in pediatric Crohn's disease: a secondary analysis of the CLARA registry study. [PDF]

Front Pediatr
Tischler L, Boerkoel A, Cantez SM, Krause H, de Laffolie J, van den Berg N.   +5 more
europepmc   +1 more source