Results 261 to 270 of about 2,875,027 (345)

Machine Learning Predictions for Assessing Hard-to-Place Deceased Donor Kidneys. [PDF]

Kidney Med
Guan G, Studnia J, Neelam S, Cheng XS, Melcher ML, Agarwal N, Somaini P, Ashlagi I.   +7 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Evaluating Tuberculosis Surveillance Using Global Standards and Benchmarks in the Philippines: Mixed Methods Study.

JMIR Public Health Surveill
Ahson M, Gaviola DM, O'Connor S, Gutierrez A, Apas M, Eguia MA, Pacial DR, Zamora A, Lacson R, De Guzman A, Moonan PK.   +10 more
europepmc   +1 more source

Population-based incidence and antimicrobial susceptibility patterns of shigellosis among children and adults from rural and urban Kenya, 2010-2019. [PDF]

PLoS One
Omore R, Ogwel B, Ochieng JB, Juma J, Omballa V, Ouma A, Aol G, Audi A, Agogo GO, Odongo G, Onyango C, Wamola N, Komo T, Chepkemoi D, Hunsperger E, Feikin DR, Montgomery JM, Widdowson MA, Prentice-Mott G, Mintz ED, Breiman RF, Munywoki PK, Bigogo GM, Verani JR.   +23 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Revisiting superradiance dynamics from single diamond nanocrystals with a physically consistent model for fluorescence decay. [PDF]

Nat Commun
Borkowski JJ, Czerwinski A, Kolenderski P.   +2 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The Communication Issue in Developing Childcare Services for Children Under Three Years of Age in China: An Analysis of Policy Texts and Practical Cases. [PDF]

Healthcare (Basel)
Liu H, Liu J.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source