Results 91 to 100 of about 7,190 (304)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Gain-aware caching scheme for information-centric networking

open access: yesTongxin xuebao, 2016
The in-network caching system of information-centric networking had to deal with the popularity of huge number of content chunks and make efficient usage of storage resources.A content popularity based caching gain opti-mization model aimed to get ...
Long CHEN   +4 more
doaj   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Efficient Coded-Block Delivery and Caching in Information-Centric Networking

open access: yesDiscrete Dynamics in Nature and Society, 2020
Information-centric networking (ICN) provides request aggregation and caching strategies that can improve network performance by reducing content server loads and network traffic.
Yan Liu   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Information-Centric Networking in Mobile and Opportunistic Networks

open access: yes, 2014
Information Centric Networking (ICN) as an emerging paradigm for the Future Internet has initially been rather focusing on bandwidth savings in wired networks, but there might also be some significant potential to support communication in mobile wireless
Vasilios A. Siris   +5 more
core   +1 more source

T-Move: A Light-Weight Protocol for Improved QoS in Content-Centric Networks with Producer Mobility

open access: yesFuture Internet, 2019
Recent interest in applications where content is of primary interest has triggered the exploration of a variety of protocols and algorithms. For such networks that are information-centric, architectures such as the Content-Centric Networking have been ...
Swaroopa Korla, Shanti Chilukuri
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Challenge and Implementation of Content-Centric Networking

open access: yesDianxin kexue, 2013
CCN is communication architecture that takes content as a primitive,and retrieves content by name,not by host IP again.It builds on publish/subscribe and network-embedded caching with bandwidth-storage tradeoff.Since it is a clean-slate design,there are ...
Xinggong Zhang, Tong Niu, Zongming Guo
doaj   +2 more sources

Design and Evaluation of Probabilistic Caching in Information-Centric Networking

open access: yesIEEE Access, 2018
In-network caching is a key feature of information-centric networking (ICN). However, challenges still exist in ICN caching such as how to place content replicas among cache nodes to maximize cache system benefits without introducing too much overhead ...
Haibo Wu   +4 more
doaj   +1 more source

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