Results 111 to 120 of about 21,204,927 (295)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Rupanyup Silos under construction

open access: yes, 2021
This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete.
Reinforced Concrete and Monier Pipe Construction Co. Pty Ltd
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Fault Diagnosis of Planetary Gearboxes Based on LSTM Improved via Feature Extraction Using VMD, Fusion Entropy, and Random Forest

open access: yesEntropy
Extracting effective fault features from the complex vibration signals of planetary gearboxes is the key to conducting efficient fault diagnosis, and it involves signal processing, feature extraction, and feature selection. In this paper, a novel feature
Xin Xia, Haoyu Sun, Aiguo Wang
doaj   +1 more source

Factors That Cause Aggressive Behavior in Adolescents

open access: yesРазвитие образования, 2019
This article is devoted to a theoretical analysis of the factors that cause aggressive behavior in adolescents. The relevance of the problem is out of question, since faced with the manifestations of aggression, teachers and psychologists experience ...
Anatolij N. Arinin, Alla L. Rasskazova
doaj   +1 more source

Lean construction: Prospects for the German construction industry [PDF]

open access: yes, 2007
There is little, if any, information available about the range and dissemination of lean concepts among construction companies in Germany. Building on the methodologies and conceptual frameworks used in earlier work in the UK (Common et al., 2000) and ...
Walter, Lorenz, Johansen, Eric
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Generic skills in design teams [PDF]

open access: yes, 2005
Recent developments in networked three dimensional (3D) virtual worlds and the\ud proliferation of high bandwidth communications technology have the potential to\ud dramatically improve collaboration in the construction industry.\ud This research project

core  

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