Results 91 to 100 of about 2,665,481 (259)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Soil environmental quality and risk assessment under combined organic pollution in a typical sewage irrigated area [PDF]

E3S Web of Conferences
Due to the shortage of freshwater and the depletion of groundwater, reuse of wastewater for crop irrigation has become essential, although many pollutants, such as antibiotics, are also introduced into the soil-groundwater system.
Du Yijing, Li Dan, Zhang Yuan, Yuan Ying, Li Jie, Jiang Yu   +5 more
doaj   +1 more source

Information Criteria Based Edge Detection

, 1998
Publication in the conference proceedings of EUSIPCO, Rhodes, Greece ...
Frédéric Jouzel, Christian Olivier, Abdelaziz El Matouat   +2 more
openaire   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Information criteria for latent factor models: a study on factor pervasiveness and adaptivity. [PDF]

J Econom, 2023
Guo X, Chen Y, Tang CY.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The capacity of human interventions to regulate PM2.5 concentration has substantially improved in China

Environment International
The rapid urbanization in China has brought about serious air pollution problems, which are likely to persist for a considerable period as the urbanization process continues. In urban areas, the spatial distribution of air pollutants represented by PM2.5
Jiachen Meng, Wenchao Han, Cheng Yuan, Lulu Yuan, Wenze Li   +4 more
doaj   +1 more source

Comment on “Transport of substantial stratospheric ozone to the surface by a dying typhoon and shallow convection” by Chen et al. (2022) [PDF]

Atmospheric Chemistry and Physics
Chen et al. (2022) analyzed the event of rapid nocturnal O3 enhancement (NOE) observed on 31 July 2021 at the surface level in the North China Plain and proposed transport of substantial stratosphere ozone to the surface by Typhoon In-fa followed by ...
X. Zheng, W. Yang, Y. Sun, Y. Sun, C. Geng, Y. Liu, X. Xu   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On the Choice of the Item Response Model for Scaling PISA Data: Model Selection Based on Information Criteria and Quantifying Model Uncertainty. [PDF]

Entropy (Basel), 2022
Robitzsch A.
europepmc   +1 more source