Results 41 to 50 of about 1,219,902 (326)

Improved Bounds on Information Dissemination by Manhattan Random Waypoint Model

, 2018
With the popularity of portable wireless devices it is important to model and predict how information or contagions spread by natural human mobility -- for understanding the spreading of deadly infectious diseases and for improving delay tolerant ...
Chu Tommy, Frias-Martinez Enrique, Johnson David B, Kleinberg Jon, Lee K, Shinki K   +5 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Social Vulnerability and Water Insecurity in the Western United States: A Systematic Review of Framings, Indicators, and Uncertainty

Water Resources Research
Water insecurity poses a complex challenge for the western United States. Large populations are exposed and susceptible to physical and social factors that can leave them with precarious access to sufficient water supplies. Consideration of social issues
Oronde Drakes, Diana Restrepo‐Osorio, Kathryn A. Powlen, Megan Hines   +3 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Unsupervised color texture segmentation based on multi-scale region-level Markov random field models [PDF]

Компьютерная оптика, 2019
In the field of color texture segmentation, region-level Markov random field model (RMRF) has become a focal problem because of its efficiency in modeling the large-range spatial constraints.
Xu Song, Liang Wu, Guoying Liu
doaj   +1 more source

Information Dissemination on Regulation of Supreme Court Number 1 Year 2016 Regarding Mediation in the Village of Maleber Bandung

Journal of Innovation and Community Engagement, 2022
As mentioned by article 1 point 1 in Regulation of the Supreme Court of the Republic of Indonesia Number 1 of 2016, mediation is an alternative resort to solve disputes through negotiation used to reach a consensus in the presence of a mediator ...
Moody R. Syailendra, Indah Aprilia, Anggraeni Sari Gunawan, Shrishti Shrishti   +3 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Interactive website on information dissemination

TELKOMNIKA (Telecommunication Computing Electronics and Control), 2021
A school is an educational institution for imparting knowledge to children. In an age where information acquisition about a school is assuming astronomical heights, the need for cost-effective and efficient information transmission methods cannot be overemphasized; hence the use of the website of a school to disseminate information is advised.
Peter O. Sadiku, Roseline Oluwaseun Ogundokun, Opeyemi Eyitayo Ogundokun, Asmau Aderonke Adebayo   +3 more
openaire   +3 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source