Results 41 to 50 of about 341,036 (265)
Journal of Innovation and Community Engagement, 2022 As mentioned by article 1 point 1 in Regulation of the Supreme Court of the Republic of Indonesia Number 1 of 2016, mediation is an alternative resort to solve disputes through negotiation used to reach a consensus in the presence of a mediator ...
Moody R. Syailendra +3 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
AtmosphereThis study aims to elucidate the influence of meteorological conditions on particle levels in Cergy-Pontoise. It explores the temporal variability of PM10 pollution days by associating them with the vertical temperature profile derived from conventional ...
Souad Lagmiri, Salem Dahech
doaj +1 more source
The crime of establishing or disseminating information that violates public morality by means of information technology [PDF]
الرافدین للحقوق, 2010 Modern technical devices represent the most supostecated phenomena of all contemporary advanced communities due to its very nature which based upon the operation of merging computer sciences with tele communications.
Nawfal Ali Abdulla, Mohammed Ezzat
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Personalised Dissemination of Legal Information
, 2019 A proper functioning of any legal system requires people to know the law. Our knowledge of the law, however, depends on how legal information are communicated. Currently, however legal information are communicated rather poorly. We are still missing opportunities that Big Data and algorithms offer in relation to how the law is published, disseminated ...
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source