Results 81 to 90 of about 2,123,568 (256)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Beyond Information Ethics - Knowledge and Care as new Values in Design
Ciência da Informação, 2015 With computer and information technology (ICT) coming to play a greater and more pervasive role in the lives of people around the world, it becomes important to consider the ways in which values and ethical beliefs are embedded in the technology that we ...
Michael Marcinkowski +1 more
doaj
Theories of Normative Ethics and Ehical Challenges in the Field of Information Management [PDF]
تحقیقات کتابداری و اطلاعرسانی دانشگاهی, 2010 Objective: Current ethical issues in information management are examined from the stand point of four major normative ethics theories (consequence-based, duty-based, right-based and virtue-based).
M Khandan
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2005 Information Ethics: Privacy and Intellectual Property provides an up-to-date discussion of the main ethical issues that face today's information-intensive society, including the areas of intellectual property rights, privacy, accessibility and censorship.
openaire +3 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Towards Ethical Information Systems: The Contribution of Discourse Ethics [PDF]
MIS Q., 2008 Ethics is important in the Information Systems field as illustrated, for example, by the direct effect of the Sarbanes-Oxley Act on the work of IS professionals. There is a substantial literature on ethical issues surrounding computing and information technology in the contemporary world, but much of this work is not published nor widely cited in the ...
John Mingers, Geoff Walsham
openaire +2 more sources