Results 141 to 150 of about 5,680,218 (316)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Design of engineering objects using the information model

open access: yesTrudy Odesskogo Politehničeskogo Universiteta, 2019
Information design of engineering objects is based on using the information models of objects. The information model allows you to create an algorithm for designing and manufacturing the desired object.
Володимир Михайлович Тігарєв   +3 more
doaj  

Method of integrated consideration of factors for calculation of anchor system of pontoons

open access: yesMagazine of Civil Engineering
The work is devoted to the study and analysis of hydrodynamic and climatic loads on hydraulic structures of the Neva Bay – the eastern part of the Gulf of Finland, which is exposed to significant anthropogenic and natural impacts.
Kozinetc Galina   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Analysising the technological parameters of the high-temperature thermomechanical treatment of metallic products

open access: yesИзвестия высших учебных заведений. Поволжский регион:Технические науки
Background. The implementation of new technologies in the manufacturing processes of structural steel products allows for the improvement of their operational properties.
V.B. Dement'ev   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The trigger-information-response model.

open access: yes, 2019
The trigger-information-response model.
Astrid Klopstad Wahl (7495685)   +4 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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