Results 191 to 200 of about 5,680,218 (316)

Understanding patrons' Micro-Level Information Seeking (MLIS) in Information Retrieval Situations.

open access: yes, 2010
[[abstract]]Elicitation is a communicative act to request information during a dialogue, which reflects the questioner's problems at hand, perplexity, interests, or perhaps internal concerns, either voluntarily or unintentionally.
Wu, Mei-Mei, 吳美美
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Information entropy and interaction optimization model based on swarm intelligence

open access: yes, 2006
By introducing the information entropy H(X) and mutual information I(X; Y) of information theory into swarm intelligence, the Interaction Optimization Model (IOM) is proposed.
Niu B(牛奔)   +3 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Coastal Zone Information Model: A comprehensive architecture for coastal digital twin by integrating data, models, and knowledge. [PDF]

open access: yesFundam Res
Yu Z   +15 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

User participation and user satisfaction in information systems development

open access: yes, 2001
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 26/06/2001.Information Systems (IS) are being developed and used in organizations to achieve their business goals and to enhance organizational ...
Bokhari, Rahat Hussain, Bokhari, R.H.
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

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