Results 171 to 180 of about 8,126,970 (354)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Information Needed [PDF]

AJN, American Journal of Nursing, 1932
openaire   +2 more sources

Contextual information needs of people in life transitions struggling with obsessive-compulsive disorder

Information Research: An International Electronic Journal
Introduction. Obsessive-compulsive Disorder (OCD) is a severe chronic mental health issue that significantly impacts people’s everyday lives. This study aims to reveal the contextual information needs of the people living with OCD during life ...
Dawei Wu, Yuxiang Chris Zhao, Yan Zhang, Shijie Song   +3 more
doaj  

Information Needs and Preferences of Men With Breast Cancer: A Qualitative Analysis of Internet Forum Posts. [PDF]

Breast J
Schemmel N, Lauberger J, Lühnen J, Steckelberg A.   +3 more
europepmc   +1 more source

Puberty and Menstruation Knowledge, Information Sources and Needs among Secondary School Adolescent Girls and Boys in Kibaha, Tanzania

Judith Msovela, Angela E. Shija, Hyasintha Ntuyeko, Calister Imeda, Aidat Mugula, Erick Mgina, Annastazia Egidio   +6 more
openalex   +2 more sources

A study of poultry farms in Enugu State Nigeria and mapping of their mechanization needs using Global Positioning System (GPS) and Geographical Information System (GIS) [PDF]

, 2018
A. Ani Ozoemena, B. Uzoejinwa B., K. N., Umebali. E. E   +3 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

More than the ABCs: assessing the information needs of school nurses. [PDF]

J Med Libr Assoc
Nickum AN, Madura K, Link JM.
europepmc   +1 more source