Results 101 to 110 of about 16,246,580 (284)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Will the Winner Take All? Competing Influences in Social Networks Under Information Overload

Applied Sciences
Competitive influence diffusion occurs in settings ranging from product competition to online information propagation. Classical models often predict winner-takes-all outcomes, whereas persistent coexistence is observed in practice.
Ninglun Gu, Zhouyang Jin, Chen Feng, Yuan Yao, Ningdi Jin, Peng Zheng, Kai Guan, Zhiyi Luo, Luoyi Fu   +8 more
doaj   +1 more source

Information Overload & Its Effect on High School Students

, 2018
This paper studies how high school students experience information overload, as well as their specific physical, emotional, and mental ...
Zimmerman, Tara
core  

Wearable art inspired by the effects of information technology at the beginning of the twenty-first century [PDF]

, 2000
Plan BThe goal of this study was to design wearable art inspired by the effects of information technology on people at the beginning of the twenty-first century. These effects included the psychological, sociological, and physiological aspects related to
King, Susan R.
core  

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Finding useful cancer information may reduce cancer information overload for Internet users

, 2020
Background: An excessive overload of information causes an ineffective management of information, stress and indefiniteness. Furthermore, this situation can prevent persons from learning and making conscious decisions.
Serçekuş Ak, Pınar, Özkan, Sevgi, Gencer, Hatice, Pınar Serçekuş, Sevgi Özkan, Hatice Gencer   +5 more
core   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Factors affecting the information overload at an managerial level

, 2015
The main purpose of this article is to analyze the factors affecting the information overload of the directors. The overload refers to the perception experienced by an individual about its incapability to manage the information needed to execute their ...
Padilla-Meléndez, Antonio, Kock, Ned, Del-Águila-Obra, Ana Rosa   +2 more
core  

Transactive memory systems as a collective filter for mitigating information overload in digitally enabled organizational groups

, 2013
With the increasing processing power and plummeting costs of information and communication technologies, the ability of employees to ubiquitously access and disseminate information grows.
Whelan, Eoin,, Teigland, Robin,
core   +1 more source