Results 41 to 50 of about 2,877,208 (241)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Millimeter-long perovskite nanowire arrays by nanogroove-confined recrystallization seamlessly integrated into high-performance photodetectors for optical imaging

Nano Research
The controlled growth of perovskite nanowires along predefined orientations offers significant advantages over traditional post-growth assembly strategies, facilitating their integration into compact functional devices.
Pingyang Huang, Wei Zhou, Rui Rong, Tiefeng Yang, Xiangtao Chen, Hanyu Liu, Wanglong Mao, Qiming Yang, Zhanhao Liang, Yanbin Chen, Xingyu Wang, Guofu Zhou, Jinyou Xu   +12 more
doaj   +1 more source

Scalable coating of HN-008N/Teflon AF1600X bilayer for electrowetting on dielectric

Results in Physics, 2021
To industrialize electrowetting on dielectric (EWOD), the performance must be maintained on the large-area substrate, where the dielectric layer plays a critical role.
Guisong Yang, Hongqing Chen, Biao Tang, Alex Henzen, Guofu Zhou   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Driving Waveform Design of Electrophoretic Display Based on Optimized Particle Activation for a Rapid Response Speed

Micromachines, 2020
Electrophoretic displays (EPDs) have excellent paper-like display features, but their response speed is as long as hundreds of milliseconds. This is particularly important when optimizing the driving waveform for improving the response speed.
Wenyao He, Zichuan Yi, Shitao Shen, Zhenyu Huang, Linwei Liu, Taiyuan Zhang, Wei Li, Li Wang, Lingling Shui, Chongfu Zhang, Guofu Zhou   +10 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Driving Waveform Optimization by Simulation and Numerical Analysis for Suppressing Oil-Splitting in Electrowetting Displays

Frontiers in Physics, 2021
Electrowetting display (EWD) is a new reflective display device with low power consumption and fast response speed. However, the maximum aperture ratio of EWDs is confined by oil-splitting.
Shufa Lai, Qinghua Zhong, Hailing Sun
doaj   +1 more source

The role of information and communication technologies in paper consumption [PDF]

International Journal of Business Information Systems, 2011
Conventionally, paper demand is modelled by using only gross domestic product and the price of paper as explanatory variables. However, one factor affecting the demand of printing and writing papers is presumably the diffusion of information and communication technologies (ICT).
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source