Results 261 to 270 of about 1,628,358 (345)

Privacy-preserving recommender system using the data collaboration analysis for distributed datasets. [PDF]

PLoS One
Yanagi T, Ikeda S, Sukegawa N, Takano Y.
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Federated learning with differential privacy for breast cancer diagnosis enabling secure data sharing and model integrity. [PDF]

Sci Rep
Shukla S, Rajkumar S, Sinha A, Esha M, Elango K, Sampath V.   +5 more
europepmc   +1 more source

Novel Solution‐Processed Fe2O3/WS2 Hybrid Nanocomposite Dynamic Memristor for Advanced Power Efficiency in Neuromorphic Computing

Advanced Science, EarlyView.
Solution‐processed approach for integration of Fe2O3/WS2 nano‐hybrid composite memristor devices. Remarkable switching characteristics and excellent durability for up to 105 cycles. The device shows ultra‐low energy consumption of 0.072 pJ and excellent environmental stability.
Faisal Ghafoor, Honggyun Kim, Bilal Ghafoor, Zaheer Ahmed, Muhammad Farooq Khan, Muhammad Rabeel, Muhammad Faheem Maqsood, Sobia Nasir, Wajid Zulfiqar, Ghulam Dastageer, Myoung‐Jae Lee, Deok‐kee Kim   +11 more
wiley   +1 more source

USING ONTOLOGIES WITH HIPPOCRATIC DATABASES - A Model for Protecting Personal Information Privacy

, 2009
Esraa Omran, Albert Bokma, Shereef Abu Al-Maati   +2 more
openalex   +1 more source

Quantitative Super‐Resolution Imaging of Molecular Tension

Advanced Science, EarlyView.
Quantitative tension PAINT (qtPAINT) is a new method to quantify molecular tension at super‐resolution by exploiting force‐dependent DNA oligonucleotide dissociation kinetics. Combining hairpin tension probes and molecular‐beacon imagers, qtPAINT achieves 9–30 pN continuous force quantification range with 30–120 nm spatial and minute‐scale temporal ...
Seong Ho Kim, Adam B. Yasunaga, Hongyuan Zhang, Kevin D. Whitley, Isaac T. S. Li   +4 more
wiley   +1 more source

Integrating differential privacy in deep reinforcement learning for sepsis treatment with pulmonary implications. [PDF]

Front Med (Lausanne)
Wang S, Yang F, Wang S, Sun R.
europepmc   +1 more source

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, EarlyView.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

Privacy Relevance and Disclosure Intention in Mobile Apps: The Mediating and Moderating Roles of Privacy Calculus and Temporal Distance. [PDF]

Behav Sci (Basel)
Chen M, Chen M.
europepmc   +1 more source