Results 31 to 40 of about 352,688 (269)

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

An enhanced DPoS consensus mechanism using quadratic voting in Web 3.0 ecosystem [PDF]

open access: yesBlockchain
Consensus mechanisms are fundamental to maintaining consistency in distributed systems. With the advent of Web 3.0, blockchain has revealed limitations of traditional Delegated Proof of Stake (DPoS) consensus mechanisms.
Tianyu Lei   +8 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Re-Evaluating Trust and Privacy Concerns When Purchasing a Mobile App: Re-Calibrating for the Increasing Role of Artificial Intelligence

open access: yesDigital, 2023
Mobile apps utilize the features of a mobile device to offer an ever-growing range of functionalities. This vast choice of functionalities is usually available for a small fee or for free.
Alex Zarifis, Shixuan Fu
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Hiding Contextual Information for Defending a Global Attacker

open access: yesIEEE Access, 2018
As wireless sensor networks are mostly deployed in harsh and hostile environments, lack of human maintenance, it has become a severe challenge to offer security or privacy service, especially when facing a powerful attacker.
Qian Zhou, Xiaolin Qin, Xiaojun Xie
doaj   +1 more source

The Approach of Legal Systems in Dealing with Invasion of Information Privacy in Social Networks [PDF]

open access: yesپژوهش تطبیقی حقوق اسلام و غرب, 2015
Invasion of information privacy is among the important legal issues that provided by social networks. In this article, we study the approach taken by legal systems in dealing with this issue and in the related subjects.
Ebrahim Abdipur
doaj   +1 more source

Human Autonomy in the Era of Augmented Reality—A Roadmap for Future Work

open access: yesInformation, 2022
Augmented reality (AR) has found application in online games, social media, interior design, and other services since the success of the smartphone game Pokémon Go in 2016.
David Harborth
doaj   +1 more source

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