Results 141 to 150 of about 848,225 (267)

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Performance of ChatGPT-4o in Providing Information on Pediatric Inborn Errors of Immunity: A Cross-Sectional Evaluation. [PDF]

J Clin Med
Taşkırdı İ, Şenbaykal Yiğit E, Eren Akarcan S, Tuncel T.   +3 more
europepmc   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

When formal governance persists but resilience does not: health system governance and resilience in Yemen across a decade of conflict and crisis (2014-2025). [PDF]

BMC Health Serv Res
Hyzam D, Boah M, Dhaiban M, Dureab F, Al-Mahbashi T, Hadi A, Al Sakkaf K, Feldmann G, Ulrichs T.   +8 more
europepmc   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, EarlyView.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

Barriers to and Facilitators of Telemedicine in Rural Healthcare in Japan: A Qualitative Analysis. [PDF]

Cureus
Matsubara D, Honda Y, Kotani K.
europepmc   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

The induction process of new professionals in the Swedish ambulance service - a document analysis. [PDF]

BMC Med Educ
Hörberg A, Wallin K, Sjölin H.
europepmc   +1 more source

Dimensional Engineering of Carbon‐Based Hybrids: From 1D Conductive Networks to 3D Porous Architectures for Next‐Generation Microwave Absorption

Advanced Science, EarlyView.
This review explores dimensional architecture engineering to overcome the impedance‐attenuation trade‐off in electromagnetic wave absorbing materials. By analyzing 1D to 3D structures and their multidimensional hybrids, we highlight synergistic mechanisms for enhanced performance.
Chuanyu Liu, Xiaoxin Guo, Xunlong Zhang, Ruiling Sun, Xingyu Zhang, Can Ge, Xuhong Yang, Yuqing Liu   +7 more
wiley   +1 more source

Development of a Rule-Based Chatbot for Supporting Family Caregivers After Psychiatric Hospital Discharge: An Exploratory Qualitative Study in Indonesia. [PDF]

J Multidiscip Healthc
Rizkiyah M, Rinawan FR, Hermansyah FR, Herawati DMD, Sukma RM.   +4 more
europepmc   +1 more source