Results 101 to 110 of about 6,269,949 (357)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

The design of a DataBase for Natural Resources in Danube Delta Biosphere Reserve DDBR

open access: yesScientific Annals of the Danube Delta Institute, 2016
Efficient use of natural resources especially in Natura 2000 sites is an essential component of Europe 2020 strategy. The use of web database is absolutely necessary for a good resource management and it will provide a good communication channel for the ...
GRIGORAS Ion   +4 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

open access: yesFEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

The Optimal Invest ment Level in Enterprise Information Resources Privacy Protection

open access: yesБезопасность информационных технологий, 2010
The enterprise information resources privacy protection is an essential concern for information security domain. The short comparison summary of actual information security investment strategies is presented. A simple and general model for the evaluating
K. S. Barabanov
doaj  

Complex information resources of a research library: modernization and development

open access: yesБиблиосфера, 2018
Library scientists have been actively considering the ways to improve various aspects of library activities recent decades. The most studied problems are the following: libraries innovative development in general, information systems updating, e ...
I. G. Yudina, E. A. Bazyleva
doaj   +1 more source

Adult Education Confronting White Christian Nationalism: A Thematic Analysis

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT As a way to conclude, this article elaborates key themes that emerged from the collected articles in this volume. Each article carries its own important message about the role of adult education in confronting White Christian nationalism, while here, Prins and Carr‐Chellman offer a thematic interpretation of the volume as a whole. These themes
Esther Prins, Davin Carr‐Chellman
wiley   +1 more source

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