Results 61 to 70 of about 5,474,324 (342)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A Constraint Generation Integer Programming Approach to Information Theoretic Sensor Resource Management [PDF]

2007 IEEE/SP 14th Workshop on Statistical Signal Processing, 2007
Many estimation problems involve sensors which can be actively controlled to alter the information received and utilized in the underlying inference task. In this paper, we discuss a novel integer programming method which exploits the submodularity of information theoretic estimation criterion to find an efficient solution to constructing an open loop ...
Jason L. Williams, John W. Fisher, Alan S. Willsky   +2 more
openaire   +1 more source

Managerial Accounting AS An Element Of Information Resources Management Of An Enterprise [PDF]

, 2020
The questions of the information resources organization and formation mechanism of an enterprise through financial and managerial reporting data and accounting data prism are highlighted.
Matiukha, M. (Mykola), Rovnyagin, A. (Alexander)   +1 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Income Tax “Need to Knows” for Military Families

EDIS
This publication discusses general information about income tax terminology, general information about income tax rules, rates, and refunds, military-specific income tax challenges, military-specific income tax regulations, five income tax planning tips
Barbara O'Neill, Martie Gillen, Kristen Jowers   +2 more
doaj   +3 more sources

Data Management Training for Graduate Students at a Large Research University

Journal of eScience Librarianship, 2012
This article describes UMass Amherst Libraries data management workshops and online resources developed for graduate students. Although students respond favorably to general “Data Management Basics” workshops, they offer suggestions for improvement and ...
Jessica Adamick, Rebecca C. Reznik-Zellen, Matt Sheridan   +2 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Audio-visual Resources and Education

Cuadernos de Documentación Multimedia, 2014
The exponential information growth requires public policies to ensure the universal access to educational resources in general and in particular to quality audiovisual resources.
Beatriz Susana Sevilla
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Designing a site-directory of web resources for a teacher of informatics

Ukrainian Journal of Educational Studies and Information Technology, 2019
The article is devoted to the study of the process of creating and designing a site-catalogue of modern web resources for its usage by informatics teacher in his professional activities.
Viktoriia Alekseienko, Olena Usata
doaj   +1 more source