Results 21 to 30 of about 6,357,689 (285)
Model-driven design of geo-information services [PDF]
, 2004 This thesis presents a method for the development of distributed geo-information systems. The method is organised around the design principles of modularity, reuse and replaceability. The method enables the modelling of both behavioural and informational
Morales Guarin, J.M. +1 more
core +2 more sources
Web services synchronization health care application
, 2011 With the advance of Web Services technologies and the emergence of Web Services into the information space, tremendous opportunities for empowering users and organizations appear in various application domains including electronic commerce, travel ...
Akaichi, Jalel, Limam, Hela
core +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
The CIARD RING, an infrastructure for interoperability of agricultural research information services [PDF]
, 2010 Creating integrated information services in agriculture giving access and adding value to information residing in distributed sources remains a major challenge.
Keizer, Johannes +2 more
core
Pathways into services for offenders with intellectual disabilities : childhood experience, diagnostic information and offence variables [PDF]
, 2010 The patterns and pathways into intellectual disability (ID) offender services were studied through case file review for 477 participants referred in one calendar year to community generic, community forensic, and low, medium, and maximum secure services.
Anthony J. Holland +18 more
core +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Investigation of eGovernment Services and Alignment between Business and Information Systems [PDF]
, 2019 Inhabitant’s implementation of eGovernment services is a key objective for the Government of developed and developing countries. However, to improve the eGovernment services it is important for any Government to align all stakeholders so that the needs ...
Alfadhel, Sulaiman +2 more
core +2 more sources
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source