Results 91 to 100 of about 2,750,407 (268)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
A defence of informational structural realism [PDF]
SSRN Electronic Journal, 2007 This is the revised version of an invited keynote lecture delivered at the 1st Australian Computing and Philosophy Conference (CAP@AU; the Australian National University in Canberra, 31 October–2 November, 2003). The paper is divided into two parts. The first part defends an informational approach to structural realism. It does so in three steps. First,
openaire +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Reconsidering asymmetries in voice-mismatched VP-ellipsis
Glossa, 2019 Previous research on VP-ellipsis has revealed the existence of a Mismatch Asymmetry, whereby cases with passive voice ellipsis clauses and active antecedent clauses are less acceptable than cases with active ellipsis clauses and passive antecedents ...
Andrew Kehler, Till Poppels
doaj +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Information Structure in Linguistics [PDF]
, 2015 Information structure is a subfield of linguistic research dealing with the ways speakers encode instructions to the hearer on how to process the message relative to their temporary mental states. To this end, sentences are segmented into parts conveying known and yet-unknown information, usually labeled ‘topic’ and ‘focus.’ Many languages have ...
openaire +2 more sources
Valores semántico-pragmáticos de aún [PDF]
Sintagma, 2016 Spanish dictionaries and grammar textbooks usually describe the word aún (even) as an expression of time and aun as an expression of modality (concession). In the first case, it is interchangeable with todavía (yet) and it carries an accent mark.
Laura D. Ferrari, Mabel Giammatteo
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Phonon-mediated unconventional superconductivity in rhombohedral stacked multilayer graphene
npj Computational MaterialsUnderstanding the origin of superconductivity in correlated two-dimensional materials is a key step in leveraging material engineering techniques for next-generation nanoscale devices.
Emil Viñas Boström +5 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source