Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Decoding the information structure underlying the neural representation of concepts. [PDF]
Proc Natl Acad Sci U S A, 2022 Fernandino L +4 more
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Design and Numerical Simulation of a Micro-Gas Turbine Combustor
Journal of Applied Fluid Mechanics, 2019 A cannular combustor with a 100-KW thermal power was designed with a swirler, primary holes, dilution holes, and cooling holes based on an original gas turbine of a practical application.
P. Zhang, Y. P. Liu, J. H. Li, Y. W. Yan
doaj
Qualia and Phenomenal Consciousness Arise From the Information Structure of an Electromagnetic Field in the Brain. [PDF]
Front Hum Neurosci, 2022 Ward LM, Guevara R.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Left Dislocation in Spoken Hebrew, it is neither topicalizing nor a construction
LinguisticsLeft Dislocation/Detachment (LD) and related constructions consist of a detached NP and a subsequent clause that conveys information about it. Information Structural approaches analyze these constructions (dubbed here “LD-type”) as cross-linguistically ...
Ozerov Pavel
doaj +1 more source
The Impact of Information Structure on the Emergence of Differential Object Marking: An Experimental Study. [PDF]
Cogn Sci, 2022 Tal S +4 more
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source