Results 211 to 220 of about 3,044,835 (268)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Genome-wide assessment of genetic diversity and population structure of Capsicum in Southwestern Colombia using DArTseq markers. [PDF]

PLoS One
Viáfara-Vega RA, Cárdenas-Henao H.
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Vib2Mol: from vibrational spectra to molecular structures-a unified deep learning framework. [PDF]

Chem Sci
Lu XY, Ma H, Li H, Li J, Rong Y, Li YQ, Zhu T, Liu GK, Ren B.   +8 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Structure-based virulence factor classification using a dual-driven graph transformer with a pretrained language model. [PDF]

Brief Bioinform
Bai P, Li G, Jiang N, Chen J, Liang C, Ding Y.   +5 more
europepmc   +1 more source

The Evolution of Artificial Intelligence in Antibody Design: From Structure-Based Engineering to Generative Models. [PDF]

Antibodies (Basel)
Szataniak I, Packi K.
europepmc   +1 more source

Structure-aware deep learning enhances m6A prediction and reveals cell type-associated RNA structural signatures. [PDF]

PLoS Comput Biol
Sun M, Zhang D, Li Z, Lin Y.
europepmc   +1 more source