Results 171 to 180 of about 5,897,591 (248)

Interventions to Promote Inclusive Governance for Underserved Populations in Sub-Saharan Africa: An Evidence and Gap Map. [PDF]

Campbell Syst Rev
Nyan CP, Manuh T, Oppong SA, Oppong M, Letsa I, Badu-Ansah NE, Ameyaw DS.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

American, British, and Italian Online Information on the Health Risks Associated With Eating Meat: Cross-Sectional Study. [PDF]

JMIR Form Res
Di Gennaro G, Licata F, Pittore P, Bianco A.   +3 more
europepmc   +1 more source

Information Studies and Education of Information Literacy

Computer & Education, 2004
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Overcoming the curse of knowledge: guidelines for reporting system-specific details of host infection and migration dynamics. [PDF]

Mov Ecol
Binning SA, Shaw AK.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Meta-analysis on comparative impact of behavioral, information, and monetary interventions on energy-efficient appliance adoption. [PDF]

PNAS Nexus
Khanna TM, Danilenko D, Tomberg L, Hansteen S, Andor MA, Lohmann PM, Neggia LR, Minx JC.   +7 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mapping Current Evidence and Research Gaps in Nutrition for Healthy Children and Adolescents: A Scoping Review. [PDF]

Nutrients
Montiel-Ojeda D, Méndez-Sánchez L, Lopez-Gonzalez D, Clark P.   +3 more
europepmc   +1 more source