Results 171 to 180 of about 36,992,088 (301)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

User-Centered Evaluation of Healthcare Information System Utilization: A Cross-Sectional Study Integrating Acceptance Models. [PDF]

Health Sci Rep
Aghilinasab F, Tanhapour M, Jebraeily M, Rahimi B.   +3 more
europepmc   +1 more source

ePortfolio as the Part of Information System

This work explains the categories of ePortfolio systems, dividing them into individual and institutional tools such as authoring tools, statistic web services, interactive web services, software - server required, hosted services, and assessment systems.
Gorbunovs, Aleksandrs
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Rural-urban disparities in high-risk non-muscle-invasive bladder cancer: lessons from the Canadian Bladder Cancer Information System. [PDF]

Transl Androl Urol
Imasuen P, Bal DS, Chung D, Nayak J.
europepmc   +2 more sources

Digitalization of the Mandatory Notifications System for Infectious Diseases in Germany: Implementation of DEMIS (the German Electronic Reporting and Information System). [PDF]

JMIR Med Inform
Suwono B, Rode O, Birghan K, Ahl H, Pape E, Krause D, Diercke M, Sievers C.   +7 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Modeling Information Systems as Systems of Systems.

, 2018
Large industrial information systems are composed of dozens of inter-operating software applications. Each of them implements a relatively independent set of functions but also participates to business processes involving more applications. Applications may be COTS acquired from different vendors or custom-developed.
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Pediatric septorhinoplasty: A cohort study utilizing the pediatric health information system (PHIS) database. [PDF]

JPRAS Open
MacIsaac MF, Hoffman RD, Wright JM, Halsey JN, Rottgers SA.   +4 more
europepmc   +1 more source