Results 251 to 260 of about 4,020,268 (318)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Unlocking the Mediating and Moderating Role of Information Security in Information Systems: A Combined TAM, ISM, and HBM Model

Human Behavior and Emerging Technologies
Md. Mominul Islam, Mohammad Rakibul Islam Bhuiyan, Syed Hasibul Islam, Mst. Nowshin Tabassum, Motasim Billah   +4 more
doaj   +1 more source

Safety and usability of oncology information systems - a systematic review. [PDF]

Front Oncol
Cihoric N, Riggenbach E, Putora PM, Dennstädt F.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Concordance of rapid diagnostic test results between health facility registers and health management information systems: a multi-country evaluation. [PDF]

Malar J
Konaté-Touré A, Ngufor C, Mpimbaza A, Atobatele S, Akpiroroh E, Ssewante N, Ahogni IB, Kouakou OMAK, Bedia-Tanoh VA, Agnon J, Affoukou C, Agaba B, Okoro O, Humes M, Griffith K, Mian ANN, Tanoh AM, Lindblade KA, Yavo W.   +18 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Harnessing digital health data for person-centred HIV prevention monitoring: a survey of national health information systems. [PDF]

J Int AIDS Soc
Dalal S, Mathers B, Stelzle D, Nyagah LM, Agbo F, Annang D, Bhavsar SP, Mbiriyawanda S, Mhlanga B, Molapo T, Moro L, Mudiope P, Ngwali L, Nyirenda MS, Sathane I, Adhikary R, Alonso Gonzalez M, Chan P, Gerritsen A, Izumi K, Kuchukhidze G, Mozalevskis A, Perrin G, Alaama AS, Tebogo M, Verster A, Low-Beer D.   +26 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A planning method for traditional villages based on natural language processing and geographic information systems. [PDF]

Sci Rep
Liu Z, Zhu Y, Zhang X, Zhu K, Hong W.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source