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The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens+8 more
wiley +1 more source
Protecting information in systems of systems [PDF]
Systems of Systems (SoS) are dynamic, distributed coalitions of autonomous and heterogeneous systems that collaborate to achieve a common goal. While o¿ering several advantages in terms of scalability and ¿exibility, the SoS paradigm has a strong impact on system interoperability and on the security requirements of collaborating parties.
Daniel Trivellato+2 more
openaire +3 more sources
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever+1 more
wiley +1 more source
Information System Efficiency as an Attribute in Environmental Information Systems [PDF]
In terms of contemporary civilization development one of the key aspects of environmental protection is the effort to avoid wasting resources. In the case of environmental information systems there is a necessity to strive for such systems, which deliver the highest benefits with the lowest possible consumption of resources (material, energy, as well ...
Koch, Miloš, Chvátalová, Zuzana
openaire +4 more sources
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink+6 more
wiley +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi+3 more
wiley +1 more source
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker+14 more
wiley +1 more source
Information Systems in Dentistry [PDF]
Almost the entire human creativity today, from the standpoint of its efficiency and expediency, is conditioned with the existence of information systems. Most information systems are oriented to the management and decision-making, including health information system. System of health and health insurance together form one of the most important segments
openaire +3 more sources
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen+13 more
wiley +1 more source
Placement Test Information Systems Student Assessment Institutions in English Course Iecpasar Rebo [PDF]
The problems faced in these institutions lies in the assessment system for the placement test students who are still done manually, which is a lot of manual system faced various obstacles and inefficiencies both in terms of time and of the workings of ...
Irfan, SKom, MMSI Irfan, SKom, MMSI+1 more
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