Results 61 to 70 of about 10,401,843 (327)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Barrier Frank-Wolfe for Marginal Inference

open access: yes, 2015
We introduce a globally-convergent algorithm for optimizing the tree-reweighted (TRW) variational objective over the marginal polytope. The algorithm is based on the conditional gradient method (Frank-Wolfe) and moves pseudomarginals within the marginal ...
Krishnan, Rahul G.   +2 more
core   +3 more sources

Part Information Systems Service Center PT. Microsis Using Microsoft Access 2000 [PDF]

open access: yes, 2005
With the implementation of information systems at the Service Center is expected to issues relating to availability of information can be solved.Given the complete data and supports the technician can more quickly and accurately analyze and repair the ...
Setyawan, A. (Adi), Usna, M. S. (MMSI)
core  

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Empirical Study of Robotic Process Automation: Implementation and Evaluation

open access: yesHuman Behavior and Emerging Technologies
Process automation has been shown to lead to significant improvements in efficiency across industries by automating certain tasks. Robotic process automation (RPA) is one such technology that is being widely implemented to gain a competitive advantage ...
Ali Gunawan   +3 more
doaj   +1 more source

Information Systems Control of Goods and Payment of PT. Vinoli Makmur [PDF]

open access: yes, 2003
In this era of globalization the world today to simplify and expedite a job, the required information accurately. Computers indispensable role in solving a variety of jobs associated with the storage, preparation of reports and update existing data.
Elsafitra, S. D. (SKom)   +1 more
core  

Protecting information in systems of systems [PDF]

open access: yes, 2011
Systems of Systems (SoS) are dynamic, distributed coalitions of autonomous and heterogeneous systems that collaborate to achieve a common goal. While o¿ering several advantages in terms of scalability and ¿exibility, the SoS paradigm has a strong impact on system interoperability and on the security requirements of collaborating parties.
Daniel Trivellato   +2 more
openaire   +3 more sources

Feed Information Systems and Expenditure on PT. Sakura Indah Photo [PDF]

open access: yes, 1996
Income and expenditure information system of goods at PT. Sakura's Beautiful photo of this, looks very easy and communicative for users live to see steps that will be done through a menu of revenue and expenditures are made in such a way with a fairly ...
Setianto, S. (Setianto), SKom, M. T. (M)
core  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Information Systems Evaluation: Approaches, Models and Methods [PDF]

open access: yesتحقیقات کتابداری و اطلاع‌رسانی دانشگاهی, 2010
Objective: The present investigation attempts to study the approaches, models and methods used for evaluating information systems. To this end, all aspects and feature of information systems and main issues in evaluation of information systems were ...
Hussein Taghavi   +2 more
doaj  

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