Results 61 to 70 of about 40,093,266 (373)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Placement Test Information Systems Student Assessment Institutions in English Course Iecpasar Rebo [PDF]

open access: yes, 2000
The problems faced in these institutions lies in the assessment system for the placement test students who are still done manually, which is a lot of manual system faced various obstacles and inefficiencies both in terms of time and of the workings of ...
Irfan, SKom, MMSI Irfan, SKom, MMSI   +1 more
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Variance Reduced Stochastic Gradient Descent with Neighbors

open access: yes, 2015
Stochastic Gradient Descent (SGD) is a workhorse in machine learning, yet its slow convergence can be a computational bottleneck. Variance reduction techniques such as SAG, SVRG and SAGA have been proposed to overcome this weakness, achieving linear ...
Hofmann, Thomas   +3 more
core   +3 more sources

Behavioral intentions in embracing cloud-based accounting information systems

open access: yesInternational Journal of Academe and Industry Research
In facing the digital era and a more competitive environment, every organization is required to increasingly implement information systems that can facilitate various organizational needs.
Yenni Carolina   +3 more
doaj   +1 more source

Information systems evaluation methodologies [PDF]

open access: yes, 2011
Due to the prevalent use of Information Systems (IS) in modern organisations nowadays, evaluation research in this field is becoming more and more important. In light of this, a set of rigorous methodologies were developed and used by IS researchers and
Chen, S.   +3 more
core  

Why emerging leaders should focus on being good postdoctoral supervisors

open access: yesFEBS Letters, EarlyView.
Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski   +5 more
wiley   +1 more source

Feed Information Systems and Expenditure on PT. Sakura Indah Photo [PDF]

open access: yes, 1996
Income and expenditure information system of goods at PT. Sakura's Beautiful photo of this, looks very easy and communicative for users live to see steps that will be done through a menu of revenue and expenditures are made in such a way with a fairly ...
Setianto, S. (Setianto), SKom, M. T. (M)
core  

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Exploiting Latent Semantic Subspaces to Derive Associations for Specific Pharmaceutical Semantics

open access: yesData Science and Engineering, 2020
State-of-the-art approaches in the field of neural embedding models (NEMs) enable progress in the automatic extraction and prediction of semantic relations between important entities like active substances, diseases, and genes.
Janus Wawrzinek   +3 more
doaj   +1 more source

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