Results 171 to 180 of about 21,736,361 (314)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Minutes: Senate Committee on Information Technologies: April 7, 2009

open access: yes, 2009
Research Cyberinfrastructure Alliance (RCA) Update, Minnesota Supercomputing Institute Update, Centralized Storage Environment UpdateUniversity of Minnesota: Senate Committee on Information Technologies. (2009).
University of Minnesota: Senate Committee on Information Technologies
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Information technologies as organizational support for the COVID-19 coping actions: Nurses' discourse. [PDF]

open access: yesRev Lat Am Enfermagem, 2023
Guedes HCDS   +5 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Minutes: Senate Committee on Information Technologies: October 3, 2006

open access: yes, 2006
ADCS/NTS/OIT Services and Resources Update, Managing Legally Protected Electronic Private Information, Committee Charge, Guidelines for Members and Chairs of University, Faculty, and StudentSenate Committee, Brainstorm Agenda Items for 2006 ...
University of Minnesota: Senate Committee on Information Technologies
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Minutes: Senate Committee on Information Technologies: February 2, 2010

open access: yes, 2010
Enhancements to Securing Data Privacy, Future BusinessUniversity of Minnesota: Senate Committee on Information Technologies. (2010). Minutes: Senate Committee on Information Technologies: February 2, 2010.
University of Minnesota: Senate Committee on Information Technologies
core  

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