FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Evaluating the effectiveness and limitations of online health information tools in assessing the quality of medication-related content. [PDF]
Front Public HealthAlhlayl AS, Alzghaibi HA.
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Crowdsourcing a Training Dataset of Question-and-Answer Pairs for AI-Enabled Health Information Tools on Sexually Transmitted Infections: Protocol for a Cross-Sectional Exploratory Survey Study. [PDF]
JMIR Res ProtocOseku E +7 more
europepmc +1 more source
INFORMATION WEAPONS AS A TOOL OF INFORMATION WARFARE
, 2022 Information weapons are a new evolutionary step on the way to the development of the latest types of weapons. Such a weapon has specific and characteristic features only for it. In the modern conditions of Russia's military aggression, the armed struggle has acquired the characteristics of not only an information war.
openaire +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Postdischarge health information tools and information needs for mothers of vulnerable newborns in low- and middle-income countries: a scoping review. [PDF]
BMJ OpenRababeh A +7 more
europepmc +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Information gateways : tool for effective digital information management
, 2004 In this information age, ICT is playing a very vital role for disseminating information to the users in the networked environment. Internet, www, Digital Library, electronic journals, online databases are all such developments, which are changing the way libraries function today.
Gudodagi, Shashikant C. +2 more
openaire +1 more source