Results 151 to 160 of about 1,406,587 (313)

Theories of information behavior

, 2005
This unique book presents authoritative overviews of more than 70 conceptual frameworks for understanding how people seek, manage, share, and use information in different contexts.
McKechnie, Lynne, Fisher, Karen E, Erdelez, Sandra   +2 more
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Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

An investigation of knowledge transfer in information systems (IS) outsourcing

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Inter-organisational knowledge transfer is of central interest both as an academic topic and in business practice.
Al-Salti, Zahran
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SYSTEMIC GENERATION OF SOLVING NECESSARY PROFESSIONAL THE TASKS

Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2015
The article explains the widespread use of mathematical modeling and computational experiment in solving scientific and technical problems. It is proved that for the construction of a good model should, be chosen major processes, order parameters ...
Vladimir M. Nesterenko
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Testing Choice Experiment for Benefit Transfer

Benefit transfer is a cost-effective method for estimating the value of environmental goods that relies on information obtained in previous studies. The multi-attribute approach of choice experiment should provide advantages in terms of benefit transfer ...
Conzalex-Roa, M.C., Calatrava-Requena, Javier, Colombo, Sergio   +2 more
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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The transfer of technology

There have been a number of studies which have attempted to identify factors affecting successful technology transfer. However, empirical studies of technology transfer, at the level of the user, have been a much neglected area of research despite ...
Walker, Anne
core  

Transfer pricing for financial institutions /

, 2001
A cutting-edge study of transfer pricing in the increasingly competitive financial services sector. It examines the many issues involved and suggests different techniques for establishing efficient transfer pricing systems. This book is essential reading
Smullen, John.
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