Results 181 to 190 of about 18,689,391 (306)

Shift-to-Shift Information Transfer: Phenomenological Study of Nurses' Experiences. [PDF]

open access: yesJMIR Nurs
Montoya-Garrido MJ   +4 more
europepmc   +1 more source

Description of boiling project burnout detector

open access: yes, 1957
Introduction: In order to effectively utilize the high heat flux available through the mechanism of nucleate boiling in forced convection heat transfer, it is of primary importance that the maximum flux or "burnout" conditions be known for the liquid ...
Reynolds John Mitchell, Raymond, M. W.
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Flujograma del subsistema de evaluación y acreditación para carreras universitarias/Flowchart of the evaluation and accreditation subsystem for university majors

open access: yesPedagogía y Sociedad
Introducción: La gestión de la calidad de los programas de carreras universitarias, requieren de información actualizada y acertada que expresen los estándares correspondientes a las variables e indicadores establecidos en el subsistema de evaluación y ...
Niurka de las Mercedes Gonzalez-Acosta   +2 more
doaj  

From Speech Semantics to Brain Activity-Timescales Are Key in Their Information Transfer. [PDF]

open access: yesHum Brain Mapp
Kumar S   +5 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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