Results 241 to 250 of about 18,075,925 (282)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Correction: Introducing the UK Crop Microbiome Cryobank data resource, AgMicrobiomeBase, with case studies and methods on metabarcoding analyses

Environmental Microbiome
Payton To Yau, Rodrigo G. Taketani, J. Miguel Bonnin, Helen Stewart, Catriona M. A. Thompson, Ian M. Clark, Tim H. Mauchline, Jacob G. Malone, Matthew J. Ryan, Susan Jones, Nicola Holden   +10 more
doaj   +1 more source

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Useful information

2008
Abstract Much of the information in this section is most easily accessed via the Internet. For those without access to a computer we have included telephone contact details.
Kevin Talbot, Rachael Marsden
openaire   +1 more source

Useful information

2021
CIfA Yearbook, 2021: Professional archaeology: a guide for ...
openaire   +1 more source

Information Search Using Holography

Applied Optics, 1972
Two methods for recording a hologram plate suitable for information search are discussed: consecutive recording of individual items on the same area of a hologram plate and parallel recording of individual identifiers on individual areas of a hologram plate.
H, Akahori, K, Sakurai
openaire   +2 more sources

Useful information

2020
This chapter provides other useful topics for nurses working in primary care or community settings. It defines telecare and telehealth, assistive technologies (ranging from special educational needs equipment to moving and handling systems) and home adaptations (including complex equipment, methods of hiring or buying disability equipment, and ...
openaire   +1 more source

Useful Information on Adoption

Pediatrics, 1972
Attention needs to be drawn to an important study of adopted children published recently by Bohman. In this 10- to 11-year follow-up study of children placed for adoption before 2 years of age by the Stockholm Adoption Agency in the mid 1950s, the health, school performance, school behavior, and school adjustment of 168 adopted children were compared ...
openaire   +2 more sources

Information use and information processing

Journal of Documentation, 2009
PurposeThe purpose of this article is to elaborate the picture of the processes of information use by comparing conceptualizations provided by the constructivist approach and the human information processing approach.Design/methodology/approachThe article is a conceptual analysis of major articles characterizing information use and human information ...
openaire   +1 more source