Results 81 to 90 of about 3,584,929 (289)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The terminology in the study of user information

open access: yesBiblios, 2013
It an exploratory study of concepts/terms to define an interdisciplinary nomenclature of a research group of Information, Design, and Usability (IDU), of the Postgraduate Program of Information Science (PPGCinf), of the University of Brasilia (UnB).
Ivette Kafure   +8 more
doaj   +1 more source

Showing the destination of hypertext links: a new approach for Guide [PDF]

open access: yes, 1992
All hypertext systems have a kind of button which can be selected interactively by the user to obtain further information. This paper is concerned with how to show the user the further information when the button is selected.
da Gracca Campos Pimentel, Maria
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Co-Innovation between a Lead User and Producers:

open access: yesMaketingu Janaru, 2019
In this paper, we discuss co-innovation between Lead Users and Producers. To practically apply the user innovation theory to product development, two methods have been used: the lead user method and user-community based theory.
Manabu Mizuno, Takahiko Kozuka
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sensory semantic user interfaces (SenSUI) [PDF]

open access: yes, 2009
Rapid evolution of the World Wide Web with its underlying sources of data, knowledge, services and applications continually attempts to support a variety of users, with different backgrounds, requirements and capabilities.
Bell, D, Heravi, BR, Lycett, M
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Integrated content presentation for multilingual and multimedia information access [PDF]

open access: yes, 2006
For multilingual and multimedia information retrieval from multiple potentially distributed collections generating the output in the form of standard ranked lists may often mean that a user has to explore the contents of many lists before finding ...
Jones, Gareth J.F., Wade, Vincent
core  

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