Results 171 to 180 of about 149,772 (265)

Electronic distance learning satisfaction, awareness, attitudes, and barriers among undergraduate nursing students following the october 7 war in Palestine. [PDF]

PLoS One
Abuejheisheh AJ, Haddad RH, Tohol WJ, Bani Hani S.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Exposure to war-related trauma and symptoms of complex posttraumatic stress disorder among children and adolescents in Gaza. [PDF]

Eur J Psychotraumatol
El-Khodary B, Iriqat R, Abo-Shamla A, Ali M, Al-Delaimy W.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Children's rights and needs during war: the case of adolescents in Israel. [PDF]

Front Psychol
Rum Y, Milsthen E, Zedan HF, Gal T.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

War-Related Disruptions and Health Service Outcomes Among Internally Displaced Persons in Tigray, Ethiopia: Evidence From Adigrat City. [PDF]

Public Health Chall
Tekulu FB, Gebre HT, Weldemichael MM, Gebrekidan EW.   +3 more
europepmc   +1 more source

Gender differences in the long-term impact of early-life exposure to war on physical and mental health: Evidence from China. [PDF]

SSM Popul Health
Zhang Z, Tang D, Wang X, Bu T, Feng Q.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Strength-based physical therapy for anxiety and depressive symptoms in a war-exposed adult: a case report. [PDF]

Oxf Med Case Reports
Maksym V, Budzyn V, Khanikiants O.
europepmc   +1 more source