Results 91 to 100 of about 33,051,848 (271)

“Information Work” and Chronic Illness: Interpreting Results from a Nationwide Survey of People Living with HIV/AIDS [PDF]

open access: yes, 2005
While there is a substantial body of research which describes how the HIV-positive community seeks and uses information, much of that work fails to consider these activities in relationship to the experience of living with long-term chronic illnesses. In
Palmer, Carole L., Hogan, Timothy P.
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Chief Information Officers Council

open access: yes, 2011
This website contains information about the Chief Information Officers Councils, which use innovative information technology (IT) in order to promote governmental transparency, accountability, and public participation.
Chief Information Officers Council (U.S.)
core  

Socioeconomic status and adolescent cannabis use: a Swedish cohort study

open access: yesJournal of Cannabis Research
Background The evidence is mixed regarding how socioeconomic status (SES) it is related to cannabis use among adolescents. This study assessed the association between parental SES, measured as the highest level of completed education, and past 12 month ...
Patrik Karlsson   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

In-work poverty in New Zealand [PDF]

open access: yes
This report examines the prevalence of, and characteristics associated with, in-work poverty in New Zealand. The analysis within this study draws primarily on linked data from Inland Revenue and the 2013 Census, as well as supplementary information ...
Plum, Alexander   +2 more
core   +5 more sources

Electronic health record adaptation and innovation among healthcare professionals in hospitals: an integrative framework based on a systematic review

open access: yesBMC Health Services Research
Background Worldwide, many hospitals have adopted an Electronic Health Record (EHR) and are currently in the post-implementation phase. To exploit EHRs to their full potential, healthcare professionals must continuously engage in adaptive behaviors to ...
Judith Engels   +5 more
doaj   +1 more source

Assessing work order information quality in harvesting

open access: yesSilva Fennica, 2017
Being a logging contractor involves several uncertainties, amongst others, information quality in the work order received from customers. The information quality of work orders is of the utmost importance for logging contactors, in order to be able to ...
Gustafsson, Åsa
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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