Results 191 to 200 of about 5,014,345 (242)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Facilitating early diagnosis of chronic thromboembolic pulmonary hypertension with dynamic chest radiography: Protocol for a multicenter, assessor-blinded, case-wise randomized superiority reader study (FIND-DCR). [PDF]

PLoS One
Hosokawa K, Yamasaki Y, Kishimoto J, Nagayama T, Adachi S, Naganawa S, Inami T, Yokoyama K, Yasuda S, Takase K, Kubota K, Yoshiura T, Sugiura T, Uno T, Kataoka M, Aoki T, Usui S, Kobayashi S, Taniguchi Y, Murakami T, Tamura Y, Fukumoto Y, Ishigami K, Abe K.   +23 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

"Either you feel bad and stay, or you're smart and leave" - perspectives from emergency department staff in Stockholm, Sweden. [PDF]

BMC Health Serv Res
Brune C, Lundmark P, Nylén L, Gustavsson M, Burström B, von Schreeb J, Liljas A.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Thinking critically about AI documentation quality in primary care. [PDF]

BMJ Qual Saf
Schiff GD, Khazen M.
europepmc   +1 more source

Developing a Social Responsibility Pilot Tool to Reduce Helicopter Research and Improve Social Benefit: A Cleanup Site Case Study. [PDF]

Environ Health Insights
Smith EM, O'James AB, Molldrem S, Hallberg L, Engel CL.   +4 more
europepmc   +1 more source

Accidents among adults in Germany - Results from the accident module of the Panel 'Health in Germany' 2024. [PDF]

J Health Monit
Saß AC, Kuhnert R.
europepmc   +1 more source

Unveiling the psychological network of work alienation among nursing interns: A resource conservation perspective and network analysis. [PDF]

PLoS One
Guo Y, Huang X, Guan C, Wang R, Yao J, Yang L, Li S.   +6 more
europepmc   +1 more source

Nurse leaders' appraisal of work-organizational interventions during COVID-19: an interview study in German hospitals and long-term care facilities. [PDF]

BMC Nurs
Zink M, Hofmann A, Wendsche J, Melzer M.
europepmc   +1 more source