Results 31 to 40 of about 820 (211)

El concepto de biblioteca nacional a partir de los tres informes de la unesco sobre las bibliotecas nacionales: Sylvestre (1.987), Line (1.989) y Cornish (1.991)

open access: yesAnales de Documentación, 2003
Entre 1.987 y 1.991 la UNESCO publicó tres informes acerca de las bibliotecas nacionales elaborados por Sylvestre, Line y Cornish. No hay unidad de criterios a la hora de analizar el concepto de biblioteca nacional, esencialmente debido a la diversidad ...
Juan José Fuentes Romero
doaj  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Producir azúcar en la Patagonia. El ingenio San Lorenzo, un malogrado proyecto de industrialización de remolacha azucarera (Rí­o Negro, 1927-1941)

open access: yesMundo Agrario, 2018
En Argentina, la demanda interna de azúcar fue provista por la industria azucarera con base en la caña, desarrollada principalmente en la región norte el paí­s.
Daniel Moyano, Susana Bandieri
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

La Aporofobia en el contexto de la sociedad peruana: una revisión

open access: yesNóesis, 2020
La investigación comienza teorizando sobre aporofobia, concepto aprobado por la Real Academia Española para referirse a la fobia a los pobres. Se revisaron documentos e informes de organismos nacionales e internacionales para caracterizar, analizar y ...
Rosmery Sabina Pozo Enciso   +1 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Public Policy Guidelines Addressing School Harassment

open access: yesLogos Ciencia & Tecnología, 2017
La presente investigación, tuvo como objetivo, dar cuenta sobre las políticas públicas que atienden el fenómeno del Acoso Escolar. Legislación internacional y nacional que orienta las intervenciones para prevenir y atender el acoso escolar.
Margarita María Cano Echeverry   +1 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

TEORÍAS DE DESARROLLO ECONÓMICO Y SOCIAL: ARTICULACIÓN CON EL PLANTEAMIENTO DE DESARROLLO HUMANO

open access: yesTendencias, 2009
El propósito fundamental de este trabajo es discutir las principales teorías del desarrollo económico y social, y articular las mismas a los conceptos fundamentales de desarrollo humano.
Giovanni Reyes
doaj  

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